The purpose of this paper will be to compare a plug and seat regulator to a control valve for high-pressure natural gas installations such as: power plants, city gate stations, large industrial customers, compressor stations, and storage fields. The features, benefits, capabilities, and differences of both devices will be outlined, to enable the reader to make an educated selection. In addition, acceptable design practices will be reviewed concerning sizing, gas velocities, noise levels, equipment layout, and performance. The ball valve is the most commonly used type of modulating valve for natural gas pipeline applications, for that reason, we will limit this discussion to comparison between the plug and seat regulator and versions of a 1/4 turn ball valve.